Why the study?
Does the combination of GH substitution and acipimox alter circulating ghrelin and leptin levels in GH-deficient patients?
Does the combination of GH substitution and acipimox alter circulating ghrelin and leptin levels in GH-deficient patients?
Antilipolysis via acipimox combined with GH administration significantly alters ghrelin and leptin levels in GH-deficient patients.
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Hypothesis-generating for ghrelin/leptin modulation in GH deficiency; does not support practice change without larger trials.
Vestergaard et al. (2005) studied this question.
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