December 21, 2004Journal of Virology

Development of a Rotavirus-Shedding Model in Rhesus Macaques, Using a Homologous Wild-Type Rotavirus of a New P Genotype

View Full Paper

Ask AI

Bookmark

Population

10 juvenile rhesus macaques for initial collection, and 8 cesarean section-derived, specific-pathogen-free…

Design

Preclinical

Follow-up

14 days

Authors

MMMonica McNealCincinnati Children's Hospital Medical Center KSKarol SestakTulane University ACAnthony H.-C. ChoiBrown University

Discussion

Member takes

Implication

Supports macaque model for asymptomatic rotavirus shedding; leaves open translation to human infection or vaccines.

Structured PICO

Population

10 juvenile rhesus macaques (2.6 to 5.9 months of age) for initial collection, and 8 cesarean section-derived, specific-pathogen-free macaques (14 to 42 days of age) for inoculation.

Intervention

Intragastric administration of a pool of wild-type TUCH rotavirus (genotype P[23]).

Outcome

Rotavirus shedding in feces and clinical symptoms (diarrhea).surrogate

The TUCH rotavirus infection in macaques provides a viable nonhuman primate model for studying rotavirus shedding and protection.

Cite This Study

McNeal et al. (2004) studied this question.

synapsesocial.com/papers/6a72b1e85d37378ac1df5c63 https://doi.org/10.1128/jvi.79.2.944-954.2005

View Full Paper

Ask AI

Bookmark

Development of a Rotavirus-Shedding Model in Rhesus Macaques, Using a Homologous Wild-Type Rotavirus of a New P Genotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Development of a Rotavirus-Shedding Model in Rhesus Macaques, Using a Homologous Wild-Type Rotavirus of a New P Genotype

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider