Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?
Population
Animal models of right ventricular failure due to chronic pressure load
Design
Review
Authors
Discussion
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Member takes
Implication
RV pathobiology supports hypothesis-generating therapies; leaves open whether beta blockers or sildenafil improve RV failure outcomes.
Structured PICO
P
Population
Animal models of right ventricular failure due to chronic pressure load
I
Intervention
Therapeutic interventions including beta blockers and sildenafil
O
Outcome
Pathophysiology and pathobiology of RV failure
This review highlights the distinct pathobiology of right ventricular failure in animal models and the ongoing need for targeted therapeutic strategies.
Cite This Study
Borgdorff et al. (2015) studied this question.