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October 24, 2006HypertensionOpen Access

Effects of Angiotensin II on NO Bioavailability Evaluated Using a Catheter-Type NO Sensor

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Why the study?

Does Angiotensin II infusion alter NO bioavailability in male New Zealand White rabbits?

Population

Male New Zealand White rabbits

Comparison

Angiotensin II infusion at 200 ng/kg per minute… vs Vehicle (sham) infusion

Design

Preclinical

Follow-up

24 hours or 14 days

Authors

TIToshio ImanishiKKKatsunobu KobayashiAKAkio Kuroi

Discussion

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Overview

Rabbit model data should not alter hypertension management; leaves open translation of Ang II–oxidative stress mechanisms to humans.

Structured PICO

Does Angiotensin II infusion alter NO bioavailability in male New Zealand White rabbits?

P
Population
Male New Zealand White rabbits
I
Intervention
Angiotensin II infusion at 200 ng/kg per minute, alone or in combination with hydralazine, valsartan, or tempol for 24 hours or 14 days
C
Comparator
Vehicle (sham) infusion
O
Outcome
Plasma NO concentration (basal and acetylcholine-induced) measured using a catheter-type NO sensor in the aortasurrogate

Chronic Angiotensin II infusion decreases NO bioavailability and increases oxidative stress in a rabbit model, which can be prevented by AT1 receptor antagonism or antioxidants.

Cite This Study

Imanishi et al. (2006) studied this question.

synapsesocial.com/papers/6a72b69bfe4101aa97e0eb63https://doi.org/10.1161/01.hyp.0000248920.16956.d8
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Also Consider

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  1. 1Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling2002 · 679 citations
  2. 2Increased activity and expression of Ca<sup>2+</sup>-dependent NOS in renal cortex of ANG II-infused hypertensive rats1999 · 50 citations
  3. 3Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations
  4. 4Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT <sub>2</sub> ) angiotensin receptor1999 · 329 citations
  5. 5Evidence That Macrophages in Atherosclerotic Lesions Contain Angiotensin II1998 · 138 citations