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June 24, 2005Circulation ResearchOpen Access

Differences Between Left and Right Ventricular Chamber Geometry Affect Cardiac Vulnerability to Electric Shocks

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Why the study?

Does the direction of externally-applied electric field (RV- vs LV- shocks) affect the vulnerability to arrhythmias in rabbit hearts?

Population

Rabbit hearts (preclinical model) and 3-D bidomain simulations

Comparison

Uniform-field, truncated-exponential, monophasic… vs Comparison between RV- shocks and LV- shocks

Design

Preclinical

Authors

BRBlanca RodríguezUniversità di CamerinoLLLi LiBGI Group (China)JEJames EasonUniversity of Memphis

Discussion

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Implication

Ventricular asymmetry shapes shock vulnerability in rabbit models; leaves open relevance to human defibrillation strategies.

Structured PICO

Does the direction of externally-applied electric field (RV- vs LV- shocks) affect the vulnerability to arrhythmias in rabbit hearts?

P
Population
Rabbit hearts (preclinical model) and 3-D bidomain simulations
I
Intervention
Uniform-field, truncated-exponential, monophasic shocks of reversed polarity (RV- or LV- shocks) applied over a range of coupling intervals
C
Comparator
Comparison between RV- shocks and LV- shocks
O
Outcome
Vulnerability area (VA) shape and probability of arrhythmia inductionsurrogate

Structural differences between the left and right ventricles affect cardiac vulnerability to electric shocks, with the direction of the shock field determining the location of the postshock excitable area and subsequent arrhythmia induction probability.

Cite This Study

Rodríguez et al. (2005) studied this question.

synapsesocial.com/papers/6a72b6a93ce530166bc35ddehttps://doi.org/10.1161/01.res.0000174429.00987.17
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Structural Complexities of Septal Tissue in Maintaining Ventricular Fibrillation in Isolated, Perfused Canine Ventricle2001 · 18 citations
  2. 2The mechanisms of the vulnerable window: the role of virtual electrodes and shock polarity2001 · 34 citations
  3. 3The mechanisms of the vulnerable window: the role of virtual electrodes and shock polarity2001 · 30 citations
  4. 4The role of cardiac tissue structure in defibrillation1998 · 141 citations
  5. 5Comparison of Upper Limit of Vulnerability and Defibrillation Probability of Success Curves Using a Nonthoracotomy Lead System1995 · 31 citations