November 1, 2003Journal of Cardiovascular ElectrophysiologyOpen Access

Optical Mapping of Transmural Activation Induced by Electrical Shocks in Isolated Left Ventricular Wall Wedge Preparations

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Population

Isolated coronary perfused preparations of porcine left ventricle (n=9)

Design

Preclinical

Authors

OSOleg F. SharifovUniversity of Alabama at Birmingham VFVladimir G. FastUniversity of Alabama at Birmingham

Discussion

Member takes

Overview

Animal data link intermediate shocks to rapid ventricular activation; leaves open translation to clinical defibrillation energy selection.

Structured PICO

Population

Isolated coronary perfused preparations of porcine left ventricle (n=9)

Intervention

Rectangular electrical shocks (duration = 10 ms; field strength, E = 1-44 V/cm) applied across preparations via large mesh electrodes during diastole or action potential (AP) plateau

Outcome

Vm responses and transmural activation patterns (latency and time of transmural activation)surrogate

Electrical shocks applied during diastole cause direct and rapid activation of the ventricular bulk, supporting the excitatory hypothesis of defibrillation.

Cite This Study

Sharifov et al. (2003) studied this question.

synapsesocial.com/papers/6a71981b75498292b70b04d7 https://doi.org/10.1046/j.1540-8167.2003.03188.x

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November 1, 2003Journal of Cardiovascular ElectrophysiologyOpen Access

Optical Mapping of Transmural Activation Induced by Electrical Shocks in Isolated Left Ventricular Wall Wedge Preparations

View Full Paper

Ask AI

Bookmark

Population

Isolated coronary perfused preparations of porcine left ventricle (n=9)

Design

Preclinical

Authors

OSOleg F. SharifovUniversity of Alabama at Birmingham VFVladimir G. FastUniversity of Alabama at Birmingham

Discussion

Member takes

Overview

Animal data link intermediate shocks to rapid ventricular activation; leaves open translation to clinical defibrillation energy selection.

Structured PICO

Population

Isolated coronary perfused preparations of porcine left ventricle (n=9)

Intervention

Rectangular electrical shocks (duration = 10 ms; field strength, E = 1-44 V/cm) applied across preparations via large mesh electrodes during diastole or action potential (AP) plateau

Outcome

Vm responses and transmural activation patterns (latency and time of transmural activation)surrogate

Electrical shocks applied during diastole cause direct and rapid activation of the ventricular bulk, supporting the excitatory hypothesis of defibrillation.

Cite This Study

Sharifov et al. (2003) studied this question.

synapsesocial.com/papers/6a71981b75498292b70b04d7 https://doi.org/10.1046/j.1540-8167.2003.03188.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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