Key result
Near-threshold diastolic field stimulation initiated early activation deep inside the myocardium rather than at the cathodal surface, suggesting surface polarization plays a minor role.
Population
Isolated coronary perfused and superfused slabs of pig right ventricular wall (n=6) stained with di-4-ANNEPS
Design
Preclinical
Authors
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Questions cathodal surface primacy in field stimulation; leaves open translation to clinical defibrillation or pacing.
This study demonstrates that during near-threshold field stimulation, early activation occurs deep within the myocardium rather than at the surface, driven by intramural virtual electrodes.
Zemlin et al. (2005) studied Arrhythmias (n=6). Near-threshold diastolic field stimulation was evaluated on Site of early activation. Near-threshold diastolic field stimulation initiated early activation deep inside the myocardium rather than at the cathodal surface, suggesting surface polarization plays a minor role.
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