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June 16, 2010IEEE Transactions on Biomedical EngineeringOpen Access

Modeling the Role of the Coronary Vasculature During External Field Stimulation

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Key result

Coronary vasculature acts as an important substrate for virtual electrode formation during external field stimulation for shocks > 8 V/cm, with induced polarizations attenuated by realistic fiber architecture and vessel wall insulation.

Why the study?

Does the presence of coronary vasculature in a computational model affect the formation of virtual electrodes during external field stimulation?

Population

Computational finite-element model of a rabbit left ventricular wedge preparation derived from…

Comparison

External electric field stimulation applied to a… vs A simplified model lacking intramural structures.

Design

Preclinical

Authors

MBMartin J. BishopPBPatrick M. BoyleGPGernot Plank

Discussion

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Overview

Incorporating coronary vasculature refines virtual electrode predictions in defibrillation models; extends computational frameworks but leaves clinical translation open.

Structured PICO

Does the presence of coronary vasculature in a computational model affect the formation of virtual electrodes during external field stimulation?

P
Population
A computational finite element model of a rabbit left ventricular wedge preparation used to investigate the role of coronary vasculature in virtual electrode formation during defibrillation shocks.
I
Intervention
External electric field stimulation (shocks of 1, 4, 10, -10, and 20 V) applied to a complex model including intramural structures (blood vessels) and histologically based fiber architecture.
C
Comparator
A simplified model lacking intramural structures (blood vessels and extracellular cleft spaces filled in).
O
Outcome
Transmembrane potential (Vm) response and formation of virtual electrodes (VEs) around blood vessels.surrogate

Coronary vasculature acts as an important substrate for virtual electrode formation during defibrillation shocks, which attenuates epicardial polarization and may aid in interpreting optical mapping data.

Limitations

  • Direct quantitative comparison of simulation results to optical mapping recordings is difficult due to distortive effects of optical mapping.
  • The model does not contain fine-scale detail regarding intermyolaminar clefts.

Cite This Study

Bishop et al. (2010) studied Ventricular fibrillation / Defibrillation. External field stimulation in the presence of detailed coronary vasculature vs. Simplified model lacking intramural structures was evaluated on Transmembrane potential response and virtual electrode formation. Coronary vasculature acts as an important substrate for virtual electrode formation during external field stimulation for shocks > 8 V/cm, with induced polarizations attenuated by realistic fiber architecture and vessel wall insulation.

synapsesocial.com/papers/6a7af2e61ba4614d7ff41685https://doi.org/10.1109/tbme.2010.2051227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of cardiac tissue structure in defibrillation1998 · 141 citations
  2. 2Intramural Virtual Electrodes During Defibrillation Shocks in Left Ventricular Wall Assessed by Optical Mapping of Membrane Potential2002 · 63 citations
  3. 3Intramural Virtual Electrodes in Ventricular Wall2004 · 21 citations
  4. 4Optical Mapping of Transmural Activation Induced by Electrical Shocks in Isolated Left Ventricular Wall Wedge Preparations2003 · 38 citations
  5. 5Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function2009 · 175 citations