Investigating the Role of the Coronary Vasculature in the Mechanisms of Defibrillation
Key result
In a rabbit ventricular computer model, the presence of intramural blood vessels accelerated reentry termination, resulting in fewer defibrillation failures (5 vs 8) compared to a simplified model.
Population
Highly anatomically detailed rabbit ventricular slice bidomain computer model constructed from 25-μm…
Comparison
Biphasic shocks applied using a realistic… vs Equivalent simplified model with intramural…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Computer models with intramural vessels suggest better defibrillation efficacy; leaves open translation to clinical shock protocols.
Structured PICO
P
Population
A highly anatomically detailed rabbit ventricular slice bidomain computer model constructed from 25-μm magnetic resonance data to study defibrillation mechanisms.
I
Intervention
Biphasic shocks (5-70 V) applied using a realistic implanted cardioverter-defibrillator electrode configuration in a model representing structural and electric properties of blood vessels
C
Comparator
Equivalent simplified model with intramural cavities filled in
O
Outcome
Defibrillation success and mechanism of reentry terminationsurrogate
Intramural blood vessels >200 μm in diameter facilitate more effective elimination of existing wavefronts and successful defibrillation by acting as virtual electrodes.
Cite This Study
Bishop et al. (2011) studied Ventricular fibrillation. Anatomically detailed model with blood vessels vs. Simplified model with intramural cavities filled in was evaluated on Defibrillation failure. In a rabbit ventricular computer model, the presence of intramural blood vessels accelerated reentry termination, resulting in fewer defibrillation failures (5 vs 8) compared to a simplified model.