Key result
Realistic 3-D simulations of the ventricular defibrillation process provide new insights into the electrical events resulting from the interaction between fibrillating myocardium and applied shocks.
Computational 3-D modeling provides critical mechanistic insights into cardiac defibrillation that cannot be resolved by current experimental techniques.
Supports computational modeling in defibrillation research; leaves open clinical translation pending validation.
Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth of the ventricles. The objective of this review article is to demonstrate that realistic 3-D simulations of the ventricular defibrillation process in close conjunction with experimental observations are capable of bringing a new level of understanding of the electrical events that ensue from the interaction between fibrillating myocardium and applied shock. The article does this by reviewing the results of two studies, one on vulnerability to electric shocks and another on defibrillation. An overview of the modelling tools used in these studies is also provided.
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Natalia A. Trayanova (2006) conducted a review in Ventricular fibrillation. 3-D simulations of ventricular defibrillation was evaluated. Realistic 3-D simulations of the ventricular defibrillation process provide new insights into the electrical events resulting from the interaction between fibrillating myocardium and applied shocks.
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