This study demonstrates the feasibility of using a bidomain computational model to simulate electrical defibrillation and post-shock arrhythmogenesis in the rabbit heart.
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May guide computational defibrillation research; leaves open human translation pending validation.
This paper presents the development of a bidomain model of electrical defibrillation and post-shock arrhythmogenesis of the rabbit heart. The model incorporates a realistic representation of cardiac geometry, fiber structure, and membrane ionic processes. Fibrillation is induced in the rabbit heart with burst pacing. Defibrillation shocks of various strengths are delivered to the model in an attempt to terminate the arrhythmia. Two sets of defibrillation simulations are conducted based on the waveform of the defibrillation shock: monophasic and biphasic. The simulations presented here demonstrate the feasibility of modeling realistically the effect of the defibrillation shock on the heart.
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Aguel et al. (2003) studied this question.
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