April 1, 1998Journal of Cardiovascular Electrophysiology

Syncytial Heterogeneity as a Mechanism Underlying Cardiac Far‐Field Stimulation During Defibrillation‐Level Shocks

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Why the study?

Does syncytial heterogeneity explain cardiac far-field stimulation during defibrillation shocks in a simulated tissue model?

Structured PICO

Does syncytial heterogeneity explain cardiac far-field stimulation during defibrillation shocks in a simulated tissue model?

Population

Simulated model of a two-dimensional region of passive cardiac tissue

Intervention

Uniform 1 V/cm longitudinal or transverse field stimuli with simulated syncytial heterogeneities (random spatial variations of intracellular volume fractions, mean fi 80%, sigma[fi] 0-10%)

Comparator

Different levels of standard deviation of intracellular volume fractions (sigma[fi] ranging from 0% to 10%)

Outcome

Shock-induced magnitudes of resulting membrane polarizationssurrogate

Syncytial heterogeneities inherent within cardiac tissue could represent a significant mechanism underlying field-induced polarizations during defibrillation shocks.

Discussion

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Implication

Syncytial heterogeneity may contribute to far-field defibrillation effects; hypothesis-generating in simulated tissue and requires in vivo validation.

Cite This Study

M.G. Fishler (1998) studied this question.

synapsesocial.com/papers/6a82b289d88fdfcf4fa0c7ff https://doi.org/10.1111/j.1540-8167.1998.tb00926.x

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Implication

Syncytial heterogeneity may contribute to far-field defibrillation effects; hypothesis-generating in simulated tissue and requires in vivo validation.

Syncytial Heterogeneity as a Mechanism Underlying Cardiac Far‐Field Stimulation During Defibrillation‐Level Shocks

Structured PICO

Discussion

Implication

Cite This Study

Syncytial Heterogeneity as a Mechanism Underlying Cardiac Far‐Field Stimulation During Defibrillation‐Level Shocks

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider