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April 5, 2002Circulation Research

Optical Mapping of Arrhythmias Induced by Strong Electrical Shocks in Myocyte Cultures

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Population

Geometrically defined myocyte cell cultures

Comparison

Uniform-field electrical shocks with strength of… vs Failed shocks or different strand widths

Design

Preclinical

Authors

VFVladimir G. FastUniversity of Alabama at BirminghamECEric R. CheekUniversity of Alabama at Birmingham

Discussion

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Overview

Shock-induced arrhythmias may originate in hyperpolarized regions with structure-dependent thresholds; hypothesis-generating for defibrillation mechanisms but leaves open clinical translation.

Structured PICO

P
Population
Geometrically defined myocyte cell cultures (cell strands with width of 0.2 and 0.8 mm, and narrow cell strands containing regions of local expansion)
I
Intervention
Uniform-field electrical shocks with strength (E) of 10 to 50 V/cm
C
Comparator
Failed shocks or different strand widths
O
Outcome
Localization of arrhythmia source and relationship with local changes of transmembrane potential (Vm)surrogate

Strong electrical shocks induce arrhythmias whose source is located in areas of shock-induced hyperpolarization, with the induction threshold depending on tissue structure.

Cite This Study

Fast et al. (2002) studied this question.

synapsesocial.com/papers/6a71981b75498292b70b04dbhttps://doi.org/10.1161/01.res.0000013403.24495.cc
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Postshock arrhythmias—a possible cause of unsuccessful defibrillation1980 · 68 citations
  2. 2Optical Transmembrane Potential Measurements During Defibrillation-Strength Shocks in Perfused Rabbit Hearts1995 · 70 citations
  3. 3Ventricular tachycardia after in vivo DC shock ablation in dogs. Electrophysiologic and histologic correlation.1991 · 15 citations
  4. 4Transthoracic ventricular defibrillation in the 100 kg calf with unidirectional rectangular pulses.1977 · 53 citations
  5. 5Nonlinear Changes of Transmembrane Potential During Defibrillation Shocks2000 · 47 citations