Key result
High-resolution optical mapping of isolated porcine left ventricles revealed both positive and negative polarizations during shocks, providing evidence for the microscopic nature of virtual electrodes.
Population
Isolated coronary-perfused porcine left ventricular preparations (n=7)
Comparison
High-resolution optical mapping of V responses… vs Low-resolution (1.2 mm/diode) optical mapping
Design
Preclinical
Authors
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Microscopic virtual electrodes may explain defibrillation discrepancies; extends theory from animal models but leaves clinical translation open.
High-resolution optical mapping demonstrates that shock-induced intramural virtual electrodes in the left ventricular wall have a microscopic origin, explaining discrepancies seen in macroscopic mapping.
Sharifov et al. (2004) studied Shock-induced intramural virtual electrodes (defibrillation mechanisms) (n=7). High-resolution optical mapping (0.11 mm/diode) vs. Low-resolution optical mapping (1.2 mm/diode) was evaluated on Shock-induced V(m) responses (polarization and activation patterns). High-resolution optical mapping of isolated porcine left ventricles revealed both positive and negative polarizations during shocks, providing evidence for the microscopic nature of virtual electrodes.
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