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April 27, 2004Circulation

Intramural Virtual Electrodes in Ventricular Wall

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Key result

Optical recordings of shock-induced transmembrane potential changes in isolated porcine left ventricles revealed significant differences between surface and global staining, indicating the presence of intramural virtual electrodes.

Population

Isolated porcine left ventricles

Comparison

Shocks applied across the ventricular wall in an… vs Comparison between surface staining and global…

Design

Preclinical

Authors

OSOleg F. SharifovUniversity of Alabama at BirminghamVFVladimir G. FastUniversity of Alabama at Birmingham

Discussion

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Overview

Hypothesis-generating for intramural virtual electrodes in defibrillation; extends optical mapping to intact myocardium but requires in vivo validation.

Structured PICO

P
Population
Isolated porcine left ventricles used to detect intramural virtual electrodes via optical recordings of shock-induced transmembrane potential changes.
I
Intervention
Shocks (2 to 50 V/cm) applied across the ventricular wall in an epicardial-to-endocardial direction during the action potential plateau via transparent mesh electrodes, with sequential staining by surface staining (SS) and global staining (GS)
C
Comparator
Comparison between surface staining (SS) and global staining (GS) optical recordings
O
Outcome
Detection of intramural virtual electrodes (IVEs) via optical recordings of shock-induced transmembrane potential (Vm) changes (DeltaVm)surrogate

Intramural virtual electrodes, potentially formed by microscopic resistive discontinuities from collagen septa, can be detected in intact myocardium using optical measurements of shock-induced transmembrane potential changes.

Cite This Study

Sharifov et al. (2004) studied this question. Global staining via coronary perfusion vs. Surface staining was evaluated on Shock-induced transmembrane potential (Vm) changes (DeltaVm). Optical recordings of shock-induced transmembrane potential changes in isolated porcine left ventricles revealed significant differences between surface and global staining, indicating the presence of intramural virtual electrodes.

synapsesocial.com/papers/6a6c210647a1bfb288f36ae2https://doi.org/10.1161/01.cir.0000127962.74368.d9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells1999 · 114 citations
  2. 2Detrimental effects of electrical fields on cardiac muscle1996 · 59 citations
  3. 3Transthoracic ventricular defibrillation in the 100 kg calf with unidirectional rectangular pulses.1977 · 53 citations
  4. 4Nonlinear Changes of Transmembrane Potential During Electrical Shocks2003 · 50 citations
  5. 5Optical Mapping of Arrhythmias Induced by Strong Electrical Shocks in Myocyte Cultures2002 · 46 citations