What question did this study set out to answer?

To determine whether endogenous Ca2+/calmodulin-dependent protein kinase IV is required for skeletal muscle fiber-type switching, mitochondrial biogenesis, and exercise-induced adaptations.

July 1, 2004AJP Cell Physiology

Skeletal muscle adaptation in response to voluntary running in Ca²⁺/calmodulin-dependent protein kinase IV-deficient mice

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Authors

TATakayuki AkimotoHiroshima University TRThomas J. RibarDuke University RWR. Sanders WilliamsDuke University

Discussion

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Implication

Animal study demonstrates preserved muscle adaptation and mitochondrial biogenesis after running in CaMKIV-deficient mice, indicating CaMKIV is dispensable for endurance training responses.

Key Points

To determine whether endogenous Ca2+/calmodulin-dependent protein kinase IV is required for skeletal muscle fiber-type switching, mitochondrial biogenesis, and exercise-induced adaptations.
Evaluated baseline muscle fiber composition, mitochondrial enzymes, and endogenous CaMKIV protein expression in wild-type and CaMKIV-knockout (Camk4-/-) mice.
Assessed plantaris muscle adaptations, including myosin heavy chain type IIa, myoglobin, PGC-1alpha, and cytochrome c oxidase IV expression, after 4 weeks of voluntary wheel running.
Measured PGC-1alpha mRNA expression in tibialis anterior muscles following 2 hours of 10-Hz motor nerve stimulation.
CaMKIV protein was undetectable in murine skeletal muscle, and baseline fiber type composition and mitochondrial enzyme levels did not differ between Camk4(-/-) and wild-type mice.
Four weeks of voluntary running increased plantaris muscle expression of myosin heavy chain type IIa, myoglobin, PGC-1alpha, and cytochrome c oxidase IV similarly in Camk4(-/-) and wild-type mice.
Acute motor nerve stimulation induced comparable increases in tibialis anterior PGC-1alpha mRNA expression in both Camk4(-/-) and wild-type mice.

Cite This Study

Akimoto et al. (2004) studied this question.

synapsesocial.com/papers/6a72b6df2163a0a01bc64219 https://doi.org/10.1152/ajpcell.00248.2004

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Implication

Animal study demonstrates preserved muscle adaptation and mitochondrial biogenesis after running in CaMKIV-deficient mice, indicating CaMKIV is dispensable for endurance training responses.

Skeletal muscle adaptation in response to voluntary running in Ca²⁺/calmodulin-dependent protein kinase IV-deficient mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Skeletal muscle adaptation in response to voluntary running in Ca²⁺/calmodulin-dependent protein kinase IV-deficient mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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