What question did this study set out to answer?

To evaluate the relationship between systemic free fatty acid (FFA) reesterification and regional FFA, glycerol, and triglyceride metabolism following prolonged fasting.

October 1, 2001AJP Endocrinology and Metabolism

Lipid metabolism during fasting

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Authors

MJMichael D. JensenPreventive Cardiology KEKarin EkbergAsarina Pharma (Sweden)BLBernard R. LandauUniversity of Vermont

Discussion

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Implication

Metabolic tracer study demonstrates systemic free fatty acid reesterification exceeds splanchnic triglyceride output in fasting men, indicating prominent nonhepatic lipid recycling.

Key Points

To evaluate the relationship between systemic free fatty acid (FFA) reesterification and regional FFA, glycerol, and triglyceride metabolism following prolonged fasting.
Assessed six men (N=6) following a 60-hour fast using indirect calorimetry to quantify resting fatty acid oxidation.
Measured systemic and regional (splanchnic, renal, and leg) FFA and glycerol kinetics using [(3)H]palmitate and [(3)H]glycerol tracer infusions alongside splanchnic triglyceride output.
Systemic FFA reesterification occurred at 366 ± 93 µmol/min, significantly exceeding splanchnic triglyceride fatty acid output of 64 ± 6 µmol/min (P < 0.05).
Systemic FFA release was approximately double the rate typically observed in overnight postabsorptive men, although regional release proportions remained unchanged.
Glycerol uptake occurred primarily within splanchnic and renal vascular beds, with minor uptake detected across the leg.

Cite This Study

Jensen et al. (2001) studied this question.

synapsesocial.com/papers/6a72b785febe604dd70abca0 https://doi.org/10.1152/ajpendo.2001.281.4.e789

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October 1, 2001AJP Endocrinology and Metabolism

Lipid metabolism during fasting

View Full Paper

Ask AI

Bookmark

Authors

MJMichael D. JensenPreventive Cardiology KEKarin EkbergAsarina Pharma (Sweden)BLBernard R. LandauUniversity of Vermont

Discussion

Member takes

Implication

Metabolic tracer study demonstrates systemic free fatty acid reesterification exceeds splanchnic triglyceride output in fasting men, indicating prominent nonhepatic lipid recycling.

Key Points

To evaluate the relationship between systemic free fatty acid (FFA) reesterification and regional FFA, glycerol, and triglyceride metabolism following prolonged fasting.
Assessed six men (N=6) following a 60-hour fast using indirect calorimetry to quantify resting fatty acid oxidation.
Measured systemic and regional (splanchnic, renal, and leg) FFA and glycerol kinetics using [(3)H]palmitate and [(3)H]glycerol tracer infusions alongside splanchnic triglyceride output.
Systemic FFA reesterification occurred at 366 ± 93 µmol/min, significantly exceeding splanchnic triglyceride fatty acid output of 64 ± 6 µmol/min (P < 0.05).
Systemic FFA release was approximately double the rate typically observed in overnight postabsorptive men, although regional release proportions remained unchanged.
Glycerol uptake occurred primarily within splanchnic and renal vascular beds, with minor uptake detected across the leg.

Cite This Study

Jensen et al. (2001) studied this question.

synapsesocial.com/papers/6a72b785febe604dd70abca0 https://doi.org/10.1152/ajpendo.2001.281.4.e789

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