Key result
Prolonged 72-hour fasting increased intramyocellular lipid content by ≈75% and decreased pyruvate dehydrogenase activity by ≈55%-60% in obese men, without a detectable effect of a GH antagonist.
Why the study?
It is unknown to what degree lipid deposition and metabolism in skeletal muscle during fasting depend on growth hormone action.
Does growth hormone antagonist treatment alter intramyocellular lipid deposition and metabolism in skeletal muscle during prolonged fasting in obese men?
Does growth hormone antagonist treatment alter intramyocellular lipid deposition and metabolism in skeletal muscle during prolonged fasting in obese men?
Growth hormone action is not required for the increase in intramyocellular lipid deposition observed during prolonged fasting in obese men.
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GH antagonism unlikely to limit fasting IMCL accumulation in obese men; hypothesis-generating for GH-independent mechanisms.
Høgild et al. (2019) studied Obesity (n=9). 72-hour fasting and growth hormone antagonist (GHA) vs. Postabsorptive state and 72-hour fasting alone was evaluated on Intramyocellular lipid (IMCL) content. Prolonged 72-hour fasting increased intramyocellular lipid content by ≈75% and decreased pyruvate dehydrogenase activity by ≈55%-60% in obese men, without a detectable effect of a GH antagonist.
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