Why the study?
Does exogenous GH replacement affect IGF and IGFBP levels during fasting with GH suppression in normal subjects?
Population
8 normal subjects
Comparison
40 h of fasting with somatostatin suppression of… vs Basal postabsorptive state; 40 h of fasting; 40…
Design
Other
Follow-up
40 hours
Authors
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May indicate GH hypersecretion in fasting is independent of IGF bioactivity; hypothesis-generating and should not change clinical practice.
Does exogenous GH replacement affect IGF and IGFBP levels during fasting with GH suppression in normal subjects?
GH hypersecretion during short-term fasting is not merely secondary to a reduction in IGF bioactivity.
Nørrelund et al. (2003) studied this question.
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