August 1, 1999AJP Endocrinology and Metabolism

Changes in the circulating IGF system during short-term fasting and refeeding in rats

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Population

Rats (n = 6-9 per group)

Comparison

Fasting and refeeding vs Baseline (0 days fasting)

Design

Preclinical

Follow-up

Up to 3 days fasting and 7 days refeeding

Authors

JFJan FrystykPreventive Cardiology PDPatric J. D. DelhantyErasmus MC CSCasper SkjærbækAarhus University

Discussion

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Implication

Fasting-induced GH/IGF changes seen in rats; leaves open human relevance and should not yet inform clinical practice.

Structured PICO

Population

Rats (n = 6-9 per group)

Intervention

Fasting (1, 2, and 3 days) and refeeding (3, 6, and 12 h and 1, 2, 3, and 7 days)

Comparator

Baseline (0 days fasting)

Outcome

Serum levels of insulin, C-peptide, growth hormone (GH), free and total IGF-I, IGFBP-1 and -3, and acid-labile subunit (ALS), as well as liver mRNA for IGF-I, IGFBP-1, and ALSsurrogate

In rats, insulin appears to regulate IGFBP-1 during fasting and refeeding, while free IGF-I changes in parallel with total IGF-I, ALS, and IGFBP-3.

Cite This Study

Frystyk et al. (1999) studied this question.

synapsesocial.com/papers/6a71a79e5d37378ac1debf64 https://doi.org/10.1152/ajpendo.1999.277.2.e245

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Changes in the circulating IGF system during short-term fasting and refeeding in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in the circulating IGF system during short-term fasting and refeeding in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider