Key result
In healthy subjects, free IGF-I decreased by 35% after insulin injection and positively correlated with insulin sensitivity in the fasting state (r=0.52, P<0.005).
Why the study?
Does acute insulin administration affect free IGF-I levels in healthy subjects?
Population
11 healthy subjects
Design
Other
Follow-up
3 hours
Authors
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Acute insulin regulation of free IGF-I suggests a role in glucose homeostasis; leaves open relevance in insulin-resistant states.
Does acute insulin administration affect free IGF-I levels in healthy subjects?
Effect estimate: r = 0.52
p-value: p=< 0.005
Free IGF-I is acutely regulated by insulin and correlates with insulin sensitivity, suggesting a physiological role in glucose homeostasis.
Nyomba et al. (1997) studied Healthy (n=11). Glucose and insulin injection was evaluated on Correlation of free IGF-I with insulin sensitivity (SI) (r = 0.52, p=< 0.005). In healthy subjects, free IGF-I decreased by 35% after insulin injection and positively correlated with insulin sensitivity in the fasting state (r=0.52, P<0.005).
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