Why the study?
Are serum levels of free and total IGF-I, IGFBP-1, and IGFBP-3 altered in IDDM patients and related to diabetic retinopathy or glomerular hyperfiltration?
Population
56 insulin-treated insulin-dependent diabetes mellitus patients and 52 healthy sex- and age-matched controls.
Design
Case-control
Authors
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Altered IGF-I and IGFBP levels in IDDM may relate to complications; case-control data leaves open predictive value for retinopathy.
Are serum levels of free and total IGF-I, IGFBP-1, and IGFBP-3 altered in IDDM patients and related to diabetic retinopathy or glomerular hyperfiltration?
In IDDM patients, serum free and total IGF-I and IGFBP-3 are decreased while IGFBP-1 is increased compared to controls, with age-adjusted free IGF-I being higher in those with diabetic retinopathy.
Janssen et al. (1997) studied this question.
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