Key result
The IGF-IGFBP axis parameters did not significantly correlate with ultrashort-, short-, or long-term diabetic control in subjects with IDDM, except for IGFBP-1 which correlated with blood glucose in young adults (r=0.57, P<0.005).
Cross-Sectional (n=39)
The IGF-IGFBP axis does not appear to reflect diabetic control in subjects with insulin-dependent diabetes mellitus under treatment.
There is some evidence that insulin-like growth factors (IGFs) and/or IGF binding proteins (IGFBPs) (IGF-IGFBP axis) may be involved in glucose metabolism. The purpose of this study was to investigate the relationship between the IGF-IGFBP axis and diabetic control in subjects with insulin-dependent diabetes mellitus (IDDM). Thirty-nine subjects with IDDM without major complications (age: 5.8-30.3 years, 13 males and 26 females) participated in this study. In all subjects, the free form of IGF-I (free IGF-I), the total IGF-I (total IGF-I: free plus complexed form of IGF-I) and IGFBP-3 in serum or plasma were measured. The Z-scores of free IGF-I, total IGF-I, and IGFBP-3 were calculated. In 18 young adults with IDDM (age 18.0-30.3 years, 5 males and 13 females), IGFBP-1 in serum was also measured. In all subjects, the diabetic control parameters such as blood glucose (BS) (momentary control), 1,5-anhydro-D-glucitol (1,5 AG) (Ultrashort-term), fructosamine (short term), and glycosylated hemoglobin (HbA1) (long-term) were measured. None of the Z scores for free IGF-I, total IGF-I or IGFBP-3 had a significant correlation with BS. In young adults, IGFBP-I was correlated with BS (r=0.57, P<0.005). None of the Z scores for free IGF-I, total IGF-I or IGFBP-3 had a significant correlation with 1,5 AG, fructosamine or HbA1. In young adults, IGFBP-1 did not correlate with 1,5 AG, fructosamine or HbA1. These data suggested that the IGF-IGFBP axis did not reflect diabetic control in subjects with IDDM under treatment.
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Hasegawa et al. (1998) conducted a cross-sectional in Insulin-dependent diabetes mellitus (IDDM) (n=39). IGF-IGFBP axis parameters (free IGF-I, total IGF-I, IGFBP-3, IGFBP-1) was evaluated on Correlation between IGF-IGFBP axis parameters and diabetic control (blood glucose, 1,5-anhydro-D-glucitol, fructosamine, and HbA1). The IGF-IGFBP axis parameters did not significantly correlate with ultrashort-, short-, or long-term diabetic control in subjects with IDDM, except for IGFBP-1 which correlated with blood glucose in young adults (r=0.57, P<0.005).
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