August 1, 1990Diabetic Medicine
Insulin‐like Growth Factor Binding Protein‐1 Levels in Diabetic Adolescents and their Relationship to Metabolic Control
Why the study?
How do fasting IGFBP-1 levels correlate with metabolic control and pubertal development in diabetic adolescents compared to normal children?
Population
32 diabetic adolescents and 69 puberty-matched normal children
Comparison
Measurement of fasting IGFBP-1 levels at 0800 h… vs Normal children (puberty-matched controls)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Associates inversely with pubertal stage and glycemic control in diabetic adolescents; leaves open whether IGFBP-1 adds value to routine monitoring.
Structured PICO
How do fasting IGFBP-1 levels correlate with metabolic control and pubertal development in diabetic adolescents compared to normal children?
P
Population
32 diabetic adolescents and 69 puberty-matched normal children
I
Intervention
Measurement of fasting IGFBP-1 levels at 0800 h after a normal night and/or after overnight euglycaemia maintained with a glucose clamp
C
Comparator
Normal children (puberty-matched controls)
O
Outcome
Fasting IGFBP-1 levels and their correlation with pubertal stage, fasting insulin levels, and glycosylated haemoglobinsurrogate
In diabetic adolescents, IGFBP-1 levels are influenced by metabolic control, with the ratio of normal to euglycaemic levels strongly correlating with glycosylated haemoglobin.
Cite This Study
Holly et al. (1990) studied this question.