What question did this study set out to answer?

To determine the impact of adolescent obesity on circulating total and free IGF-I concentrations as well as IGF-binding proteins 1, 2, and 3.

May 1, 1998The Journal of Clinical Endocrinology & Metabolism

The Metabolic Syndrome and Insulin-Like Growth Factor I Regulation in Adolescent Obesity1

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Why the study?

Does obesity alter the insulin-like growth factor (IGF)/IGF-binding protein (IGFBP) system in adolescents?

Key Points

To determine the impact of adolescent obesity on circulating total and free IGF-I concentrations as well as IGF-binding proteins 1, 2, and 3.
Evaluated 19 obese adolescents (age 14 ± 1 years; BMI 34 ± 3), 20 lean adolescents (age 14 ± 1 years; BMI 23 ± 0.5), and 10 lean adults (age 22 ± 0.7 years; BMI 22 ± 0.7).
Measured basal circulating levels of growth hormone, insulin, total and free IGF-I, and IGFBP-1, -2, and -3.
Assessed acute hormonal regulation during a two-step (8 and 40 mU/m²) euglycemic hyperinsulinemic clamp.
Fasting insulin was significantly elevated in obese adolescents, while basal IGFBP-1 was markedly reduced (14 ± 3 ng/mL) and inversely related to insulin (r = -0.49; P < 0.01).
Obese adolescents had lower total IGF-I, basal growth hormone, and IGFBP-3 levels, yet exhibited normal to increased levels of biologically active free IGF-I.
IGFBP-1 levels showed no further suppression during the hyperinsulinemic clamp in obese adolescents, unlike the rapid suppression observed in lean adults.

Structured PICO

Does obesity alter the insulin-like growth factor (IGF)/IGF-binding protein (IGFBP) system in adolescents?

Population

49 subjects including 19 obese adolescents (14 +/- 1 yr old; BMI, 34 +/- 3), 20 lean adolescents (14 +/- 1 yr old; BMI, 23 +/- 0.5), and 10 lean adults (22 +/- 0.7 yr; BMI, 22 +/- 0.7)

Intervention

Two-step 8 and 40 mU/m2 insulin clamp

Comparator

Lean adolescents and lean adults

Outcome

Circulating total and free IGF-I levels and IGFBP-1, -2, and -3surrogate

Compensatory hyperinsulinemia in adolescent obesity chronically suppresses IGFBP-1 levels, which may increase the bioavailability of free IGF-I.

Discussion

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Implication

Obese adolescents' suppressed IGFBP-1 may raise free IGF-I bioavailability; hypothesis-generating for IGF system changes, needs prospective confirmation.

Cite This Study

Attia et al. (1998) studied this question.

synapsesocial.com/papers/6a852fb7563dbb7b86d97e45 https://doi.org/10.1210/jcem.83.5.4827

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Implication

Obese adolescents' suppressed IGFBP-1 may raise free IGF-I bioavailability; hypothesis-generating for IGF system changes, needs prospective confirmation.

The Metabolic Syndrome and Insulin-Like Growth Factor I Regulation in Adolescent Obesity1

Key Points

Structured PICO

Discussion

Implication

Cite This Study

The Metabolic Syndrome and Insulin-Like Growth Factor I Regulation in Adolescent Obesity1

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider