Population
39 children (22 obese and 17 age-matched controls)
Design
Case-control
Authors
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May support altered GH/IGF binding as mechanism preserving growth in obese children; leaves open need for prospective validation before clinical application.
In obese children, normal growth despite reduced GH secretion may be maintained by increased total GHBP and reduced IGFBP-2, which increases tissue IGF-I bioavailability.
Ballerini et al. (2004) studied this question.
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