Why the study?
Does weight reduction on a calorie-restricted diet normalize the GH-IGF axis in prepubertal children with exogenous obesity?
Population
65 prepubertal children with exogenous obesity
Comparison
Weight reduction on a calorie-restricted diet vs Controls
Design
Cohort
Follow-up
Until 25% and 50% reduction in BMI SD score
Authors
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Weight reduction normalizes GH but not IGF/insulin abnormalities in obese children; hypothesis-generating for adjunctive interventions beyond BMI reduction.
Does weight reduction on a calorie-restricted diet normalize the GH-IGF axis in prepubertal children with exogenous obesity?
In prepubertal children with exogenous obesity, weight reduction normalizes GH secretion but does not fully reverse abnormalities in the peripheral IGF system and hyperinsulinemia.
Argente et al. (1997) studied this question.
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