September 1, 1999Diabetes/Metabolism Research and ReviewsOpen Access

Circulating levels of free insulin‐like growth factors in obese subjects: the impact of Type 2 diabetes

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Population

93 subjects including lean subjects, obese subjects without Type 2 diabetes, obese subjects with Type 2…

Design

Cross-sectional

Authors

JFJ. FrystykThe University of Sydney CSC. Skjærbæk EVE. Vestbo

Discussion

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Implication

Obesity-linked GH/IGF shifts should not yet change practice; leaves open causal roles and diabetes-specific effects needing longitudinal data.

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Population

93 subjects including lean subjects (n=26), obese subjects without Type 2 diabetes (n=24), obese subjects with Type 2 diabetes (n=29), healthy subjects (n=7), and Type 1 diabetic subjects (n=7).

Outcome

Overnight fasting serum levels of free and total (extractable) IGF-I and -II, IGF-binding protein (IGFBP) -1, -2 and -3, and the high affinity GH-binding protein (GHBP)surrogate

Simple obesity is associated with marked changes in the GH/IGF system, some of which are accentuated or normalized by the concomitant presence of Type 2 diabetes.

Cite This Study

Frystyk et al. (1999) studied this question.

synapsesocial.com/papers/6a8a3b492a1069eaeccbee5e https://doi.org/10.1002/(sici)1520-7560(199909/10)15:5<314::aid-dmrr56>3.3.co;2-5

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Implication

Obesity-linked GH/IGF shifts should not yet change practice; leaves open causal roles and diabetes-specific effects needing longitudinal data.

Circulating levels of free insulin‐like growth factors in obese subjects: the impact of Type 2 diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Circulating levels of free insulin‐like growth factors in obese subjects: the impact of Type 2 diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider