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June 1, 1992The Journal of Clinical Endocrinology & Metabolism

Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans.

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Why the study?

Does insulin infusion differentially regulate plasma IGFBP-1 levels in obese compared to nonobese women?

Population

18 women (10 obese and 8 nonobese)

Comparison

Sequential saline infusion, hyperinsulinemia and… vs Obese vs nonobese women

Design

Other

Follow-up

330 minutes

Authors

CCCheryl A. ConoverMayo ClinicPLPhillip LeeUniversity of Southern CaliforniaJKJill A. KanaleyUniversity of Missouri

Discussion

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Implication

Preserved hepatic IGFBP-1 suppression by insulin in obesity despite peripheral resistance; leaves open clinical relevance for metabolic outcomes.

Structured PICO

Does insulin infusion differentially regulate plasma IGFBP-1 levels in obese compared to nonobese women?

P
Population
18 women (10 obese and 8 nonobese)
I
Intervention
Sequential saline infusion (0-90 min), hyperinsulinemia (insulin infusion; 90-210 min) and hypoinsulinemia (somatostatin + GH infusion; 210-330 min)
C
Comparator
Obese vs nonobese women
O
Outcome
Plasma IGFBP-1 levelssurrogate

Hepatic insulin sensitivity in terms of IGFBP-1 production is preserved despite peripheral insulin resistance in obesity, as low IGFBP-1 levels are related to elevated baseline insulin levels.

Cite This Study

Conover et al. (1992) studied this question.

synapsesocial.com/papers/6a82d8be9aaf5d32a4b28e83https://doi.org/10.1210/jcem.74.6.1375600
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of the Growth Hormone-Independent Growth Factor-Binding Protein in Children1988 · 101 citations
  2. 2Regulation of Growth Hormone-Independent Insulin Like Growth Factor-Binding Protein (BP-28) in Cultured Human Fetal Liver Explants*1989 · 123 citations
  3. 3Insulin-Like Growth Factor (IGF) and IGF-Binding Proteins: Comparison of Human Serum and Lymph*1988 · 219 citations
  4. 4Dose-response characteristics for effects of insulin on production and utilization of glucose in man1981 · 704 citations
  5. 5Soluble 34K Binding Protein Inhibits the Binding of Insulin-like Growth Factor I to Its Cell Receptors in Human Secretory Phase Endometrium: Evidence for Autocrine/Paracrine Regulation of Growth Factor Action*1988 · 252 citations