November 1, 1991The Journal of Clinical Endocrinology & Metabolism

Abnormal Regulation of Insulin-Like Growth Factor Binding Proteins in Adolescents with Insulin-Dependent Diabetes*

View Full Paper

Ask AI

Bookmark

Population

52 adolescents with insulin-dependent diabetes and 74 puberty-matched control subjects with short stature…

Design

Case-control

Authors

JBJennifer BatchJacksonville University RBRobert C. BaxterThe University of Sydney GWGeorge A. WertherCommonwealth Scientific and Industrial Research Organisation

Discussion

Member takes

Implication

May link IGFBP dysregulation to growth impairment in diabetic adolescents; leaves open causal role and need for prospective studies.

Structured PICO

Population

52 adolescents with insulin-dependent diabetes and 74 puberty-matched control subjects with short stature and normal hormonal status

Comparator

74 puberty-matched control subjects with short stature and normal hormonal status

Outcome

Fasting 0800 h insulin-like growth factor binding proteins (IGFBP)-1 and IGFBP-3 levelssurrogate

Adolescents with insulin-dependent diabetes exhibit abnormal regulation of IGFBPs, with elevated IGFBP-1 potentially contributing to growth impairment and the dawn phenomenon.

Cite This Study

Batch et al. (1991) studied this question.

synapsesocial.com/papers/6a7797c01400807f0f1eb81d https://doi.org/10.1210/jcem-73-5-964

View Full Paper

Ask AI

Bookmark

Abnormal Regulation of Insulin-Like Growth Factor Binding Proteins in Adolescents with Insulin-Dependent Diabetes*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Abnormal Regulation of Insulin-Like Growth Factor Binding Proteins in Adolescents with Insulin-Dependent Diabetes*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider