August 1, 1991Acta Paediatrica
Impact of Increased Growth Hormone Secretion on Carbohydrate Metabolism in Adolescents with Diabetes
Why the study?
Does increased growth hormone secretion impact carbohydrate metabolism and insulin requirements in adolescents with IDDM?
Population
26 adolescents with insulin-dependent diabetes mellitus (IDDM) and 34 healthy siblings
Comparison
Overnight growth hormone secretory profile… vs Healthy siblings and intra-individual comparison
Design
Cross-sectional
Authors
Discussion
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Implication
GH hypersecretion may link to dawn phenomenon in adolescent IDDM; hypothesis-generating, needs prospective trials before practice change.
Structured PICO
Does increased growth hormone secretion impact carbohydrate metabolism and insulin requirements in adolescents with IDDM?
P
Population
26 adolescents with insulin-dependent diabetes mellitus (IDDM) and 34 healthy siblings
I
Intervention
Overnight growth hormone (GH) secretory profile measurement under normal insulin regimen (n=15), euglycaemic clamp (n=26), and euglycaemic clamp with pirenzepine to suppress GH secretion (n=7)
C
Comparator
Healthy siblings (n=34) and intra-individual comparison (with vs. without pirenzepine)
O
Outcome
Overnight GH secretory profiles (pulse amplitude, baseline GH concentrations, and frequency of secretory episodes)surrogate
Adolescents with IDDM exhibit persistent abnormalities in growth hormone secretion and IGF-I despite normoglycemia, which directly contribute to metabolic disturbances such as the dawn phenomenon.
Cite This Study
Dunger et al. (1991) studied this question.