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September 1, 1983New England Journal of Medicine

Insulin-like Growth Factors

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Why the study?

Are serum concentrations of IGF I and IGF II associated with the severity of diabetic retinopathy in adult patients with diabetes?

Population

142 subjects, comprising 80 adult patients with diabetes and 62 control subjects.

Comparison

Measurement of serum insulin-like growth factors… vs Control subjects and diabetic patients without…

Design

Cross-sectional

Authors

EFE. R. Froesch

Discussion

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Overview

IGF-I elevation flags high-risk Type 1 diabetes retinopathy; hypothesis-generating, prospective studies needed before clinical adoption.

Structured PICO

Are serum concentrations of IGF I and IGF II associated with the severity of diabetic retinopathy in adult patients with diabetes?

P
Population
142 subjects, comprising 80 adult patients with diabetes (including 7 with Type I diabetes and rapidly deteriorating vision due to proliferative and exudative retinopathy, and 26 with Type I diabetes without or with less severe retinopathy) and 62 control subjects.
I
Intervention
Measurement of serum insulin-like growth factors (IGF I and IGF II) levels
C
Comparator
Control subjects and diabetic patients without severe retinopathy
O
Outcome
Serum concentrations of IGF I and IGF IIsurrogate

Elevated serum concentrations of IGF I identify patients with Type I diabetes at high risk for rapid deterioration of vision due to retinopathy.

Cite This Study

E. R. Froesch (1983) studied this question.

synapsesocial.com/papers/6a7d28222d005ba2c41cc993https://doi.org/10.1056/nejm198309013090904
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.1978 · 1,550 citations
  2. 2Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*1980 · 747 citations
  3. 3EVIDENCE FROM RADIOLIGAND ASSAYS THAT SOMATOMEDIN-C AND INSULIN-LIKE GROWTH FACTOR-I ARE SIMILAR TO EACH OTHER AND DIFFERENT FROM OTHER SOMATOMEDINS11980 · 159 citations
  4. 4Effect of Pubertal Stage and Recent Blood Glucose Control on Plasma Somatomedin C in Children with Insulin-dependent Diabetes Mellitus1981 · 87 citations
  5. 5Diabetic retinopathy and the fibrinolytic system1975 · 64 citations