Key result
Diabetes was associated with threefold lower IGF-I mRNA levels in human retinas compared to nondiabetic controls (P=0.005), whereas IGF-IR activation and signaling were not decreased.
Population
Human postmortem retinas from 6 diabetic donors and 6 age-matched nondiabetic donors, as well as retinas…
Comparison
Diabetes mellitus (disease state) vs Nondiabetic age-matched controls
Design
Preclinical
Authors
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Should not yet alter retinopathy management; leaves open compensatory IGF-IR signaling despite reduced IGF-I.
Observational (n=12)
p-value: p=0.005
IGF-I mRNA levels are reduced in the diabetic retina of humans and rats, but IGF-IR activation and signaling remain unaffected, suggesting compensatory mechanisms.
Gerhardinger et al. (2001) conducted an observational in Diabetic retinopathy (n=12). Diabetes vs. Nondiabetic controls was evaluated on IGF-I mRNA levels (p=0.005). Diabetes was associated with threefold lower IGF-I mRNA levels in human retinas compared to nondiabetic controls (P=0.005), whereas IGF-IR activation and signaling were not decreased.
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