Key result
IGF-1 signaling has complex effects on diabetic retinopathy, potentially aggravating retinal deterioration through endothelial cell proliferation despite beneficial blood glucose normalization.
Population
Patients with diabetic retinopathy
Design
Review
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Warrants caution with IGF-1 therapies in diabetes; leaves open net retinal effects in diabetic retinopathy.
This review highlights the complex role of IGF-1 in diabetic retinopathy, noting its potential to improve blood glucose control while simultaneously risking aggravation of retinal deterioration via mitogenic pathways.
A 2015 study conducted a review in Diabetic Retinopathy. IGF-1 signaling was evaluated. IGF-1 signaling has complex effects on diabetic retinopathy, potentially aggravating retinal deterioration through endothelial cell proliferation despite beneficial blood glucose normalization.
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