Key result
GH blockade with pegvisomant during a 72-hour fast in obese males abrogated fasting-induced insulin resistance (P<0.01), primarily due to reduced endogenous glucose production (P=0.003).
Why the study?
Does GH blockade with pegvisomant improve insulin sensitivity and substrate metabolism during fasting in obese males?
RCT (n=9)
randomized
Does GH blockade with pegvisomant improve insulin sensitivity and substrate metabolism during fasting in obese males?
p-value: p=<0.01
Suppression of GH activity during fasting in obese subjects reverses insulin resistance and amplifies insulin-stimulated suppression of lipid intermediates.
GH blockade may reverse fasting-induced insulin resistance in obese men; hypothesis-generating for metabolic effects during prolonged fasting.
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Pedersen et al. (2017) conducted an RCT in Obesity (n=9). GH blockade (pegvisomant) vs. Overnight fast (control) and 72-hour fasting was evaluated on Fasting-induced insulin resistance (p=<0.01). GH blockade with pegvisomant during a 72-hour fast in obese males abrogated fasting-induced insulin resistance (P<0.01), primarily due to reduced endogenous glucose production (P=0.003).
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