Key result
Prolonged fasting for 60 hours decreased insulin sensitivity by 45% and increased FFA concentrations 5-fold in healthy lean men, but did not change inflammatory cytokine concentrations.
Why the study?
Does prolonged fasting alter inflammatory cytokines and adipokines in healthy lean men?
Population
10 healthy young lean men (mean BMI: 22.8 kg/m2)
Comparison
Fasting for 60 hours vs Fed in energy balance for 60 hours
Design
RCT, In random order
Follow-up
60 hours
Authors
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Challenges systemic inflammation as mediator of FFA-induced insulin resistance; extends mechanistic evidence in healthy lean men.
RCT (n=10)
random order
Does prolonged fasting alter inflammatory cytokines and adipokines in healthy lean men?
Prolonged fasting induces insulin resistance and increases free fatty acids without altering inflammatory cytokines, suggesting that FFA-induced insulin resistance is not mediated by systemic inflammation in healthy lean men.
Herpen et al. (2012) conducted an RCT in Healthy (n=10). Prolonged fasting vs. Fed in energy balance was evaluated on Concentrations of inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8) and hs-CRP. Prolonged fasting for 60 hours decreased insulin sensitivity by 45% and increased FFA concentrations 5-fold in healthy lean men, but did not change inflammatory cytokine concentrations.
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