Pharmacologic Therapy for Type 2 Diabetes Mellitus

Letters4 July 2000Pharmacologic Therapy for Type 2 Diabetes MellitusRalph A. DeFronzo, MDRalph A. DeFronzo, MDUniversity of Texas Health Science Center at San Antonio; San Antonio, TX 78229 (DeFronzo)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:After publication of my article on therapy for type 2 diabetes (1), the Food and Drug Administration (FDA) withdrew troglitazone as monotherapy for the treatment of patients with this disease. The FDA has approved two new thiazolidinediones, rosiglitazone and pioglitazone, for this indication. A revised algorithm (Figure) takes into account these actions taken by the FDA.Figure.Revised pharmacologic algorithm for treatment of patients in whom type 2 diabetes is inadequately controlled with diet and exercise.FPG = fasting plasma glucose; HbA1c = hemoglobin A1c; HBGM = home blood glucose monitoring. * Goals and therapies must be individualized; † Preferred if patient is obese ...Reference1. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131:281-303. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Health Science Center at San Antonio; San Antonio, TX 78229 (DeFronzo) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPharmacologic Therapy for Type 2 Diabetes Mellitus Ralph A. 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in drug-naive type 2 diabetesAdiposity, hyperinsulinemia, diabetes and Alzheimer's diseaseIncretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1Diabetes in WomenThe entero-insular axis: implications for human metabolismDiabetic Control AgentsMuscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individualsExenatide: first-in-class incretin mimetic for the treatment of Type 2 diabetes mellitusIncretin Mimetics and Dipeptidyl Peptidase-IV Inhibitors: Potential New Therapies for Type 2 Diabetes MellitusType 2 diabetes mellitus and metabolic syndromeType 2 Diabetes Mellitus in Youth: The Complete Picture to DateTratamiento no farmacológico y farmacológico de la diabetes mellitusCardiovascular risk in type 2 diabetics and pharmacological regulation of mealtime glucose excursionsHyperinsulinaemia and hyperglycaemia: possible risk factors of colorectal cancer among diabetic patientsInsulin and Hypoglycemic AgentsTratamiento farmacológico de la diabetes mellitus tipo 2Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic GluconeogenesisImpaired glucose tolerance: do pharmacological therapies correct the underlying metabolic disturbance?PPARγ AND G LUCOSE H OMEOSTASISInsulin Resistance: Concepts, Controversies, and the Role of Nutrition 4 July 2000Volume 133, Issue 1Page: 73-74KeywordsAlgorithmsDietDrug therapyExerciseFood and Drug AdministrationHemoglobinHypoglycemicsPatientsType 2 diabetes Issue Published: 4 July 2000 CopyrightCopyright © 2000 by American College of Physicians. 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