Why the study?
Does single-dose etomidate increase mortality and adrenal insufficiency in patients with severe sepsis and septic shock requiring rapid sequence intubation?
Does single-dose etomidate increase mortality and adrenal insufficiency in patients with severe sepsis and septic shock requiring rapid sequence intubation?
The use of single-dose etomidate for rapid sequence intubation in patients with sepsis is associated with increased risks of adrenal insufficiency and all-cause mortality.
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Avoid etomidate for RSI in sepsis; confirms higher mortality and adrenal insufficiency risks.
Chan et al. (2012) studied this question.
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