Key result
Etomidate administration in critically ill patients was associated with a trend toward increased in-hospital mortality compared to alternative induction agents (RR 1.20; 95% CI 0.99-1.45).
Why the study?
Does etomidate increase in-hospital mortality in critically ill patients requiring mechanical ventilation?
Cohort (n=824)
Yes
Does etomidate increase in-hospital mortality in critically ill patients requiring mechanical ventilation?
Relative Risk: 1.2 (95% CI 0.99–1.45)
In critically ill patients requiring intubation, etomidate induction is associated with a trend toward increased in-hospital mortality and a significantly higher risk of critical illness-related corticosteroid insufficiency.
No takes yet. Share an insight, caveat, or question.
Should not change induction practices; leaves open etomidate mortality effect in randomized trials.
Sunshine et al. (2012) conducted a cohort in critically ill patients (n=824). Etomidate vs. alternative induction agent was evaluated on in-hospital mortality (RR 1.20, 95% CI 0.99-1.45). Etomidate administration in critically ill patients was associated with a trend toward increased in-hospital mortality compared to alternative induction agents (RR 1.20; 95% CI 0.99-1.45).
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