May 1, 1984The Journal of PhysiologyOpen Access

The effects of valinomycin on ion movements across the sarcoplasmic reticulum in frog muscle.

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Population

Frog semitendinosus muscles

Comparison

Valinomycin (5 microM) vs Untreated frog muscles

Design

Preclinical

Authors

TKTakio KitazawaRakuno Gakuen University ASA P SomlyoAmpel BioSolutions (United States)ASAvril V. SomlyoVascular / Pulmonary Vascular

Discussion

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Implication

Animal data preclude clinical application; leaves open whether Ca2+ release is electrogenic in mammalian muscle.

Structured PICO

Population

Frog semitendinosus muscles

Intervention

Valinomycin (5 microM)

Comparator

Untreated frog muscles

Outcome

Elemental composition and fractional volume of the terminal cisternae (t.c.) of the sarcoplasmic reticulum (s.r.)surrogate

Valinomycin increases K+ permeability in the sarcoplasmic reticulum of frog muscle, allowing charge neutralization during Ca2+ release and suggesting that Ca2+ release is an electrogenic process.

Cite This Study

Kitazawa et al. (1984) studied this question.

synapsesocial.com/papers/6a72bac1f44fa9f079e01abb https://doi.org/10.1113/jphysiol.1984.sp015199

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The effects of valinomycin on ion movements across the sarcoplasmic reticulum in frog muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effects of valinomycin on ion movements across the sarcoplasmic reticulum in frog muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider