Why the study?
Cardiovascular dysfunction often appears before overt hyperglycemia and diabetes onset, raising questions about whether perivascular adipose tissue and vascular smooth muscle cell interactions drive this early dysfunction.
Does conditioned medium from metabolically stressed adipocytes impair vascular smooth muscle cell function?
Does conditioned medium from metabolically stressed adipocytes impair vascular smooth muscle cell function?
Metabolic challenge of adipocytes induces the release of soluble mediators that impair vascular smooth muscle cell function, suggesting a mechanism for early cardiovascular dysfunction prior to overt hyperglycemia.
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Early CV assessment warranted in prediabetes; leaves open mechanistic targets and clinical interventions.
Rafeh et al. (2019) studied this question.
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