Key result
High-fat diet fails to alter maximal aortic contraction in male rats.
Why the study?
Increased fat intake, a major determinant of central obesity, may influence smooth muscle cell reactivity and perivascular adipose tissue-mediated vascular function through oxidative stress mechanisms.
Absolute Event Rate: 3.6% vs 3.5%
p-value: p=0.96
Mechanistic data on fat intake, SMC reactivity, and PVAT oxidative stress remain preliminary; leaves open any clinical role in metabolic vascular disease.
Visceral obesity, a feature of the metabolic syndrome, is associated with metabolic and cardiovascular diseases. Our aim was to study the influence of increased fat intake, a major determinant of central obesity, on Smooth Muscle Cells (SMC) reactivity and its interaction with Perivascular Adipose Tissue (PVAT), which plays an important role in the local regulation of vascular function, with a special emphasis on oxidative stress.
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A 2017 study studied Diet-induced central obesity and insulin resistance (n=36). High-Fat Diet (HFD) vs. Low-Fat Diet (LFD) was evaluated on Phenylephrine-induced maximal contraction of endothelium-denuded aortic rings (p=0.96). A 5-month high-fat diet in male rats did not significantly alter phenylephrine-induced maximal aortic contraction (3.60 g vs 3.50 g, P=0.96) due to a new equilibrium state in oxidative stress.
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