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Design
Review
Supports structured exploration of genetic influences on drug response; leaves open translation to routine clinical practice.
Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.
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Roden et al. (2011) studied this question.
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