What question did this study set out to answer?

To assess the prevalence and nature of subclinical echocardiographic abnormalities in asymptomatic, normotensive children and young adults with insulin-dependent diabetes.

January 1, 1983Diabetes Care

High Prevalence of Echocardiographic Abnormalities in Diabetic Youths

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Why the study?

Do young insulin-dependent diabetic subjects have a higher prevalence of echocardiographic abnormalities compared to age-matched controls?

Population

743 youths, comprising 107 insulin-dependent diabetic subjects aged 2-24 years and 636 age-group matched…

Design

Case-control

Authors

ZLZuhdi LababidiUniversity of Missouri Hospital DGDavid E. GoldsteinUniversity of New Mexico

Discussion

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Implication

Young patients with insulin-dependent diabetes exhibit a high prevalence of echocardiographic abnormalities, which may represent early signs of preclinical cardiomyopathy.

Key Points

To assess the prevalence and nature of subclinical echocardiographic abnormalities in asymptomatic, normotensive children and young adults with insulin-dependent diabetes.
Evaluated 107 normotensive, asymptomatic insulin-dependent diabetic subjects (aged 2–24 years, mean 13.8 ± 0.4 years) and 636 age-matched controls using M-mode echocardiography.
Measured cardiac dimensions and interventricular septum dynamics, evaluating correlations with age, diabetes duration, plasma glucose, and hemoglobin A1c levels.
Diabetic subjects had significantly increased mean dimensions of the left atrium, right ventricle, and left ventricle during both systole and diastole (P < 0.01).
Interventricular septum excursion was significantly reduced in diabetic subjects compared to controls (3.9 ± 0.1 mm vs. 5.6 ± 0.2 mm; P < 0.01), with 15% of diabetic subjects versus 0% of controls exhibiting excursions below 3 mm.
Cardiac abnormalities increased with age but did not correlate with diabetes duration, ambient plasma glucose concentrations, or hemoglobin A1c levels.

Structured PICO

Do young insulin-dependent diabetic subjects have a higher prevalence of echocardiographic abnormalities compared to age-matched controls?

Population

743 youths, comprising 107 insulin-dependent diabetic subjects aged 2-24 years (mean age 13.8 years) and 636 age-group matched controls. All patients were normotensive and free of cardiorespiratory symptoms.

Outcome

Echocardiographic abnormalities, including dimensions of the left atrium, right ventricle, left ventricle, and interventricular septum excursionsurrogate

Young patients with insulin-dependent diabetes exhibit a high prevalence of echocardiographic abnormalities, which may represent early signs of preclinical cardiomyopathy.

Cite This Study

Lababidi et al. (1983) studied this question.

synapsesocial.com/papers/6a72c09eb5c1fe5ca9e004f4 https://doi.org/10.2337/diacare.6.1.18

Topics

Echocardiography Cardiomyopathy

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Implication

Young patients with insulin-dependent diabetes exhibit a high prevalence of echocardiographic abnormalities, which may represent early signs of preclinical cardiomyopathy.

High Prevalence of Echocardiographic Abnormalities in Diabetic Youths

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

High Prevalence of Echocardiographic Abnormalities in Diabetic Youths

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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