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January 1, 2001Japanese Circulation Journal-english EditionOpen Access

Spontaneous Onset of Torsade de Pointes in Long-QT Syndrome and the Role of Sympathovagal Imbalance.

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Population

2 high-school students diagnosed with long-QT syndrome, followed up without medical treatment, with no prior…

Design

Case_series

Authors

AFAkira FujikiHeart Rhythm SocietyKNKunihiro NishidaNishida HospitalKMKoichi MizumakiMurata (Japan)

Discussion

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Implication

Sympathovagal imbalance may trigger TdP in LQTS; hypothesis-generating case data requiring prospective validation before any practice implications.

Structured PICO

P
Population
2 high-school students (16- and 17-year-old boys) diagnosed with long-QT syndrome, followed up without medical treatment, with no prior history of syncope or arrhythmia induction by treadmill exercise tests.
O
Outcome
Dynamic changes between the RR and QT intervals associated with the spontaneous onset of torsade de pointes (TdP) during Holter ECG monitoringsurrogate

Sympathovagal imbalance, characterized by sinus tachycardia followed by abrupt bradycardia, may play an important role in the dynamic change of the QT interval and initiation of TdP in patients with long-QT syndrome.

Cite This Study

Fujiki et al. (2001) studied this question.

synapsesocial.com/papers/6a72c0e975498292b70bb4efhttps://doi.org/10.1253/jcj.65.1087
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The long QT syndrome. Prospective longitudinal study of 328 families.1991 · 973 citations
  2. 2Changes in atrial and ventricular refractoriness and in atrioventricular nodal conduction produced by combinations of vagal and sympathetic stimulation that result in a constant spontaneous sinus cycle length.1987 · 118 citations
  3. 3Effects of Unilateral Stellate Ganglion Block on the Spectral Characteristics of Heart Rate Variability1999 · 61 citations
  4. 4Relation Between Autonomic Nerve Activity and QT Interval in Patients with Congenital Long QT Syndrome: Analysis Using 24‐Hour Holter ECG Monitoring1998 · 6 citations
  5. 5Time- and Rate-Dependent Alterations of the QT Interval Precede the Onset of Torsade de Pointes in Patients With Acquired QT Prolongation1997 · 48 citations