Why the study?
Are QT interval dynamics that precede torsade de pointes consistent with initiation by early afterdepolarization-induced triggered activity in patients with acquired QT prolongation?
Are QT interval dynamics that precede torsade de pointes consistent with initiation by early afterdepolarization-induced triggered activity in patients with acquired QT prolongation?
Critical prolongation of the QT interval precedes the onset of torsade de pointes, supporting the hypothesis that the initial complex is an early afterdepolarization-induced triggered response.
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Supports EAD-triggered activity in acquired torsade; hypothesis-generating and requires prospective confirmation before clinical application.
Gilmour et al. (1997) studied this question.
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