Time- and Rate-Dependent Alterations of the QT Interval Precede the Onset of Torsade de Pointes in Patients With Acquired QT Prolongation
Why the study?
Are QT interval dynamics that precede torsade de pointes consistent with initiation by early afterdepolarization-induced triggered activity in patients with acquired QT prolongation?
Population
7 patients with acquired prolongation of ventricular repolarization who had one or more episodes of torsade…
Design
Case_series
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Supports EAD-triggered activity in acquired torsade; hypothesis-generating and requires prospective confirmation before clinical application.
Structured PICO
Are QT interval dynamics that precede torsade de pointes consistent with initiation by early afterdepolarization-induced triggered activity in patients with acquired QT prolongation?
P
Population
7 patients with acquired prolongation of ventricular repolarization who had one or more episodes of torsade de pointes
O
Outcome
Relation between RR and QT intervals before, during and after multiple episodes of torsade de pointessurrogate
Critical prolongation of the QT interval precedes the onset of torsade de pointes, supporting the hypothesis that the initial complex is an early afterdepolarization-induced triggered response.
Cite This Study
Gilmour et al. (1997) studied this question.