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December 1, 2024Malignancy SpectrumOpen Access

Assessment of risk prediction scores for venous thromboembolism in ambulatory cancer patients with solid tumors receiving chemotherapy: A comparative analysis

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Why the study?

Cancer patients have a 4-7-fold increased risk of thrombotic complications, and comparing risk assessment models could enable early identification of high-risk ambulatory patients who would benefit from thromboprophylaxis.

Which risk assessment model best predicts venous thromboembolism in ambulatory cancer patients receiving chemotherapy?

Population

230 ambulatory cancer patients with solid malignancy undergoing chemotherapy

Comparison

Khorana vs PROTECHT vs CONKO vs COMPASS-CAT risk scores

Design

Single-center prospective cross-sectional study

Authors

HMHamsaveni MuthukumarWJW.M. JoseAmrita Institute of Medical Sciences and Research CentreNHNikhil Krishna HaridasAmrita Institute of Medical Sciences and Research Centre

Discussion

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Member takes

Overview

Risk model comparisons for cancer-associated VTE remain hypothesis-generating; leaves open optimal tool for guiding thromboprophylaxis.

Structured PICO

Which risk assessment model best predicts venous thromboembolism in ambulatory cancer patients receiving chemotherapy?

P
Population
n=230 ambulatory cancer patients with solid malignancy undergoing chemotherapy
I
Intervention
VTE risk assessment models (Khorana, PROTECHT, CONKO, and COMPASS-CAT scores)
C
Comparator
Comparison among the different risk assessment models
O
Outcome
Accuracy of predicting venous thromboembolism (VTE)

The Khorana score is the most accurate risk assessment model for predicting venous thromboembolism in ambulatory cancer patients undergoing chemotherapy.

Cite This Study

Muthukumar et al. (2024) studied this question.

synapsesocial.com/papers/6a72c12d75498292b70bb533https://doi.org/10.1002/msp2.54
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of risk prediction scores for venous thromboembolism in cancer patients: a prospective cohort study2017 · 234 citations
  2. 2Risk factors for chemotherapy‐associated venous thromboembolism in a prospective observational study2005 · 574 citations
  3. 3Risk-assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews2020 · 62 citations
  4. 4Venous Thromboembolism Prophylaxis2013 · 75 citations
  5. 5Evaluation of the Khorana, PROTECHT, and 5‐SNP scores for prediction of venous thromboembolism in patients with cancer2021 · 36 citations