In vitro study demonstrates human herpesvirus 6 infection in aortic endothelial cells, suggesting a potential viral role in mediating vascular injury.
Herpesviruses have been proposed as potential mediators of vascular injury (3). In particular, indirect evidence links human cytomegalovirus (HCMV) infection with the development of vascular diseases, including coronary artery disease, vascular sclerosis, and arterial restenosis (2), but a clear role for the virus has yet to be established. In addition to HCMV, other herpesviruses can infect endothelial cells. Human herpesvirus 6 (HHV-6) has a preferential tropism for CD4 T lymphocytes but can infect endothelial cells in vitro (5).
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Rotola et al. (2000) studied this question.
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