What question did this study set out to answer?

To identify the specific lymphocyte subsets targeted and infected by human herpesvirus 6 (HHV-6)-related virus in clinical cases and cord blood samples.

July 1, 1989Journal of VirologyOpen Access

Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus

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Authors

KTKazuo TakahashiFujita Health University SSShunro SonodaJapan Medical Association KHK HigashiOkinawa Prefecture

Discussion

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Implication

In vitro analysis demonstrates selective viral replication in mature CD4+ T lymphocytes from exanthem subitum patients, indicating predominant CD4 T-cell tropism of human herpesvirus 6.

Key Points

To identify the specific lymphocyte subsets targeted and infected by human herpesvirus 6 (HHV-6)-related virus in clinical cases and cord blood samples.
Isolated viral particles from peripheral blood lymphocyte subsets (CD4+ CD8-, CD3+ CD4+, CD4- CD8+, CD4- CD8-, and CD3-) obtained from patients with exanthem subitum.
Inoculated cord blood mononuclear cell subpopulations characterized by distinct CD3, CD4, and CD8 surface markers to assess viral infection rates.
HHV-6-related virus was successfully isolated from mature CD4+ CD8- and CD3+ CD4+ T lymphocytes, but failed to isolate from CD4- CD8+, CD4- CD8-, or CD3- T cells in patient peripheral blood.
Viral infection occurred predominantly in CD4+ CD8+, CD4+ CD8-, and CD3+ CD4+ cells exhibiting mature phenotypes, while CD4- CD8+ cord blood mononuclear cells were rarely infected.

Cite This Study

Takahashi et al. (1989) studied this question.

synapsesocial.com/papers/6a74494851ce19f076092ff7 https://doi.org/10.1128/jvi.63.7.3161-3163.1989

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Implication

In vitro analysis demonstrates selective viral replication in mature CD4+ T lymphocytes from exanthem subitum patients, indicating predominant CD4 T-cell tropism of human herpesvirus 6.

Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus

Discussion

Member takes

Implication

Key Points

Cite This Study

Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider