Key result
In vitro infection with HHV-6A resulted in differential viral gene expression between CD4+ T lymphocytes and primary human astrocytes at 5 days post-infection.
Population
CD4+ T lymphocytes and primary human astrocytes derived from brain biopsy material in vitro
Comparison
Infection with HHV-6A strain vs Comparison between infected CD4+ T lymphocytes…
Design
Preclinical
Follow-up
5 days post-infection
Authors
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Hypothesis-generating for HHV-6A glial tropism; leaves open any clinical relevance to neuroinflammation.
HHV-6A exhibits differential gene expression in primary human astrocytes compared to CD4+ T lymphocytes, suggesting an alternative replication strategy to evade immune detection in neural glial cells.
Yao et al. (2006) studied HHV-6A infection. HHV-6A infection vs. CD4+ T lymphocytes vs primary human astrocytes was evaluated on Viral gene expression at peak viral load levels. In vitro infection with HHV-6A resulted in differential viral gene expression between CD4+ T lymphocytes and primary human astrocytes at 5 days post-infection.
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